Molecular Mechanism of Brain Development Leads to the Mind and Behavior
The human brain is made up of approximately one hundred billion neurons, forming complex neural networks and thereby controlling mind and behavior. But how does the brain develop and work properly? Answering this question is not only a critical issue for the life sciences but is also vital to society, for which an increase in neurodevelopmental disorders has become a major public health concern. Thus, overall, our group aims to elucidate the molecular mechanisms underlying brain development and its disorders. We identify genes related to neuronal, synaptic, and circuit development via a neuroinformatics perspective in the mouse cerebellar cortical circuit, and furthermore analyze their function by employing a multidisciplinary approach from the molecular to behavioral level.
The article on the role of Homer2/Cupidin in synaptic transmission in cerebellar granule cells was published in Molecular Brain.
The article on the involvement of CAPS2 in rubber hand illusion (a kind of body ownership illusion) (results of collaboration with Dr. Wada's group at REHAB) was published in Front. Behav. Neurosci.
The article on the role of CAPS2 in oxytocin release and social behavior was published in Journal of Neuroscience.
The article on the role of CAPS1 in synaptic plasticity and learning behavior was published in Scientific Reports.
The article on a rare SNV of human PHYHIPL (results of collaboration with Dr. Sadakata's group at Gunma Univ) was published in Molecular Brain.
The article on the brain transcriptome of BTBR/R mice was published in Frontier in Cellular Neuroscience.
The article on CAPS2-dependent proopiomelanocortin release involved in food intake behavior was published in Neuroscience Letters.
The article on the cortico-amygdala interaction in taste memory retrieval was published in Molecular brain.
The article on neuronal excitability in fear memory formation was published in Scientific Reports.
The article on essential tremor-like behavior in small GTPase Arf4/5 KO mice (results of collaboration with Dr. Sadakata at Gunma Univ.) was published in Journal of Neuroscience.
The article on impaired rubber tail illusion in CAPS2 KO mice (results of collaboration with Dr. Wada at Research Institute of National Rehabilitation Center for Persons with Disabilities) was published in Scientific Reports.
The article on increased startle response to auditory and tactile stimuli in LAMP5 KO mice was published in Molecular Brain.
The article on BDNF and NT-3 levels in various brain regions of CAPS2 KO mice was published in Biochem. Biophys. Res. Commun.
The article on ViBrism, a brain gene expression atlas database (results of collaboration with Drs. Morita K. & Okamura-Oho Y.) was published in Nucleic Acid Res..
Two graduate students Ms. Konami Abe and Mr. Shuhei Fujima
received the "Junior Investigator Poster Award" at The 41st Annual Meeting of the Japan Neuroscience Society, Neuroscience 2018.
The article on aberrant synapse development of hippocampal mossy fibers in CAPS2 mice was published in Neurosci Lett.
The article on impaired long-term memory formation of RNG105/caprin1 KO mice (results of collaboration with Dr. Shiina's group at NIBB) was published in eLife.
The article of Yagishita et al. waspublished in Neuroscience Letters (Environmental enrichment-induced adult neurogenesis in CAPS2 KO mice).
The article on deltamethrin increases neurite outgrowth via BDNF/TrkB pathway (results of collaboration with Drs. Fukuchi & Tsuda) was published in Cell Structure and Function.
The article of Hayashi et al. was published in PLoS ONE (Brain specific RasGEF very-KIND KO mice).
The article of Sadakata et al. was published in Neurosci. Lett. (GeneChip analysis of CAPS2 KO mouse cerebellum).
The article of Fumio Yoshikawa, Yumi Sato, et al was published in PLoS ONE (Myelin paranodal membrane protein Opalin KO mice).
The article of Yo Shinoda, Yui Nakajima, Hirotoshi Iguchi, et al was published in European Journal of Pharmacology (Galacto-N-biose is neuroprotective).
The article of Yo Shinoda and Chiaki Ishii was published in Scientific Reports (CAPS1 regulates exocytosis of synaptic vesicles).
Yui Nakajima's article on the protective effect of citrinin against glutamate-induced neurotroxicity was published in J. Toxicol. Sci.
Waseda Univ Inoue Lab - TUS Furuichi Lab Joint Retreat @Waseda
BrainTx (formerly CDT-DB)
The Brain Transcriptome Database (BrainTx) project aims to create an integrated platform to visualize and analyze our original transcriptome data and publicly accessible transcriptome data related to the genetics that underlie the development, function, and dysfunction stages and states of the brain. BrainTx was developed from the Cerebellar Development Transcriptome Database (CDT-DB).