Department of Applied Biological Science (HP: English / 日本語)

Faculty of Science and Technology (HP: English / 日本語)

Tokyo University of Science (HP: English / 日本語)

© 2013 by Lab of Molecular Neuroscience.

   All rights reserved.

東京理科大学 理工学部 応用生物科学科

     My current research interests are in (1) studying the molecular mechanisms of brain development

and its disorders and (2) attempting to systematize the transcriptomicbasis underlying the postnatal

development of mouse cerebellum.

 

     We now focus on the study of synapses and circuits by analyzing function and expression of

several brain development-related genes including CAPS2/Cadps2 (a dense-core vesicle secretion

-related protein that promotes BDNF secretion kinetics and is thought to be associated with autism

susceptibility), very-KIND/Kndc1 (a MAP2-binding RasGEF that regulates dendrite growth), Cupidin/Homer2 (a postsynaptic scaffold protein that regulates morphology of postsynapses via interacting with actin cytoskeleton regulators Drebrin and Cdc42), p130Cas/Bcar1 (an adaptor protein that links the Src protein tyrosine kinase signaling and the actin cytoskeleton signaling to regulate growth cone extension), Opalin/Tmem10 (a sialylglyco-transmembrane protein localized in the paranodal loop membrane of the mammalian CNS myelin), and phospholipase D 4 (PLD4, an atypical PLD family member expressed in microglia).

 

     I acts as the project leader of the Cerebellar Development Transcriptome Database (CDT-DB) (http://www.cdtdb.neuroinf.jp) that is a neuroinformatics database containing a large amount of the information regarding the spatiotemporal expression patterns of genes involved in the postnatal development of mouse cerebellum and is supported by the RIKEN Neuroinformatics Japan Center (NIJC), Japan Node of the International Neuroinformatics Coordination Facility (INCF).

 

 

Research experience:

Professor, Tokyo University of Science (2011-present)

Part-time Team Leader, RIKEN Brain Science Institute (2011)

Laboratory Head, RIKEN Brain Science Institute (1999-2010)

Visiting Professor, Saitama University Brain Science Institute (2009-2010)

Visiting Professor, Hiroshima University Graduate School of Biomedical Sciences (2009-2010)

Associate Professor, Institute of Medical Science, University of Tokyo (1992-1998)

Research Associate, National Institute for Basic Biology (1989-1991)

Postdoctoral Fellow, National Institute for Basic Biology (1986-1988)

Postdoctoral Fellow, State University of New York at Stony Brook (1986)

 

 

PUBLICATION LIST

Original publications

  1. Shinoda Y., Sadakata T., Yagishita K., Kinameri E., Katoh-Semba R., Sano Y., Furuichi T. Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3. Biochem. Biophys. Res. Commun. 509 (2):429-434, 2019.

  2. Morita M, Shimokawa K, Nishimura M, Nakamura S, Tsujimura Y, Takemoto S, Tawara T, Yokota H, Wemler S, Miyamoto D, Ikeno H, Sato A, Furuichi T, Kobayashi N, Okumura Y, Yamaguchi Y, Okamura-Oho Y. ViBrism DB: an interactive search and viewer platform for 2D/3D anatomical images of gene expression and co-expression networks. Nucleic Acid Res. 47: Database issue, D859-D866, 2019.

  3. Shinoda Y, Sadakata T, Akagi T, Sakamaki Y, Hashikawa T, Sano Y, Furuichi T. Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals development in hippocampal mossy fiber terminals. Neurosci Lett. 677:65-71, 2018.

  4. Nakayama K., Ohashi R., Shinoda Y., Yamazaki M., Abe M., Fujikawa A., Shigenobu S., Futatsugi A., Noda M., Mikoshiba K., Furuichi T., Sakimura K., and Shiina N. RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. eLife 6: e29677, 2017.

  5. Yagishita K., Suzuki R., Mizuno S., Katoh-Semba R., Sadakata T., Sano Y., Furuichi T., Shinoda Y. CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus. Neuroscience Letters 661:121-125, 2017

  6. Ihara D., Fukuchi M., Katakai M., Shinoda Y., Katoh-Semba R., Furuichi T., Ishikawa M., Tabuchi A., Tsuda M. Deltamethrin increases neurite outgrowth in cortical neurons through endogenous BDNF/TrkB pathways. Cell Structure and Function 42(2): 141-148, 2017

  7. Hayashi K, Furuya A, Sakamaki Y, Akagi T, Shinoda Y, Sadakata T, Hashikawa T, Shimizu K, Minami H, Sano Y, Nakayama M, and Furuichi T. The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination. PLoS ONE 12(3):e0173175, 2017

  8. Sadakata, T., Shinoda, Y., Ishizaki, Y., and Furuichi, T. Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways. Neurosci. Lett. 639: 88-93, 2017

  9. Yoshikawa, F., Sato, Y., Tohyama, K., Akagi, T., Furuse, T., Sadakata, T., Tanaka, M., Shinoda, Y., Hashikawa, T., Itohara, S., Sano, Y., Ghandour, SM., Wakana, S., and Furuichi, T. Mammalian-specific central myelin protein Opalin is redundant for normal myelination: structural and behavioral assessments. PLoS ONE 11(11): e0166732, 2016

  10. Shinoda, Y., Nakajima, Y., Iguchi, H., Tatsumi, S., Kitaoka, M., Nakajima, M., Takahashi, T., Fujiwara, M., and Furuichi, T. Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro. Eur. J. Pharmacol. 791: 711-717, 2016

  11. Shinoda, Y., Ishii, C., Fukazawa, Y., Sadakata, T., Ishii, Y., Sano, Y., Iwasato, T., Itohara, S., and Furuichi, T. CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3–CA1 synapses in adult hippocampus. Sci. Rep. 6:31540, 2016

  12. Nakajima, Y., Iguchi, H., Kamisuki, S., Sugawara, F., Furuichi, T., Shinoda, Y. Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. J. Toxicol. Sci., 41:311-319, 2016

  13. Hosono, M., Shinoda, Y., Hirano, T., Ishizaki, Y., Furuichi, T., Sadakata, T. Interaction of Ca2+-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain. Neurosci. Lett. 617: 232–235, 2016

  14. Mishima, Y., Shinoda, Y., Sadakata, T., Kojima, M., Wakana, S., and Furuichi, T. Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice. Sci. Rep. 5:8932, 2015

  15. Okamura-Oho, Y., Shimokawa, K., Nishimura, M., Takemoto, S., Sato, A., Furuichi, T., and Yokota, H. Broad integration of expression maps and co-expression networks compassing novel gene functions in the brain. Sci. Rep. 4:6969, 2014

  16. Sato, Y., Yoshikawa, F., Sadakata, T., Shinoda, Y., Koebis, M., and Furuichi, T. Age-dependent redistribution and hypersialylation of the central myelin paranodal loop membrane protein Opalin in the mouse brain. Neurosci. Lett. 581:14-19, 2014

  17. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Saruta, C., Ishizaki, Y., Yuzaki, M., Kojima, M., and Furuichi, T. Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum. PLoS ONE 9(6):e99524, 2014

  18. Tanabe, K., Yamazaki, H., Inaguma, Y., Asada, A., Kimura, T., Takahashi, J., Taoka, M., Ohshima T., Furuichi, T., Isobe, T., Nagata, K., Shirao, T., and Hisanaga, S. Phosphorylation of Drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. PLoS ONE 9(3): e92291, 2014

  19. Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba,R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki, M., and Furuichi, T. CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J. Neurosci., 33:17326-17334, 2013

  20. Motoyoshi-Yamashiro, A., Tamura, M., Moriyama, M., Takano, K., Kawabe, K., Nakajima, H., Katoh-Semba, R., Furuichi, T., and Nakamura, Y. Activation of cultured astrocytes by amphotericin B: Stimulation of NO and cytokines production and changes in neurotrophic factors. Neurochem. Int. 63:93-100, 2013.

  21. Tanaka, M., Shih, PY., Gomi, H., Yoshida, H., Nakai, J., Ando, R., Furuichi, T., Mikoshiba, K., Semyanov, A., and Itohara, S. Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses. Mol. Brain 6:6, 2013

  22. Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., and Furuichi, T. Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene. FEBS Lett. 587:54-59, 2013

  23. Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., Sato, Y., Saruta, C., Miwa, H., Tanaka, M., Itohara, S., and Furuichi, T. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice. Proc. Natl. Acad. Sci. U.S.A. 109:21104-21109, 2012

  24. Fujita, H., Morita, N., Unno, T., Furuichi, T., and Sugihara, I. Clustered fine compartmentalization of the mouse embryonic cerebellar cortex is rearranged into the postnatal striped organization. J. Neurosci. 32:15688-15703, 2012.

  25. Sadakata, T., Sekine, Y., Oka, M., Itakura, M., and Furuichi, T. Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 279:384-394, 2012

  26. Otani, Y., Yamaguchi, Y., Sato, Y., Furuichi, T., Ikenaka, K., Kitani, H., and Baba, H. PLD4 is involved in phagocytosis of microglia: expression and localization changes of PLD4 are correlated with activation state of micrglia. PLoS One 6(11):e27544, 2011.

  27. Hamatake, M., Miyazaki, N., Sudo, K., Matsuda, M., Sadakata, T., Furuya, A., Ichisaka, S., Hata, Y., Nakagawa, C., Nagata, K., Furuichi, T., Katoh-Semba, R. Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats. J. Biol. Chem. 286:21478-21487, 2011

  28. Huang, J., Furuya, A., Hayashi, K., and Furuichi, T. Interaction between very-KIND RasGEF and MAP2, and its role in dendrite growth: structure and function of the second kinase non-catalytic C-lobe domain. FEBS J. 278:1651-1661, 2011

  29. Shinoda, Y., Sadakata, T., Nakao, K., Katoh-Semba, R., Kinameri, E., Furuya, A., Yanagawa, Y., Hirase, H., and Furuichi, T. Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network. Proc. Natl. Acad. Sci. U.S.A. 108:373-378, 2011

  30. Masuya, H., Makita, Y., Kobayashi, N., Nishikata, K., Yoshida, Y., Mochizuki, Y., Doi, K., Takatsuki, T., Waki, K., Tanaka, K., Ishii, M., Matsushima, A., Takahashi, S., Mizoguchi, R., Kozaki, T., Furuichi, T., Kawaji, H., Wakana, S., Nakamura, Y., Yoshiki, A., Murata, T., Fukami-Kobayashi, K., Mohan, S., Ohara, O., Hayashizaki, Y., Obata, Y., and Toyoda, T. The RIKEN integrated database of mammals. Nucleic Acids Res. 39:D861-870, 2011

  31. Yoshikawa, F., Banno, Y., Otani, Y., Yamaguchi, Y., Nagakura-Takagi, Y., Morita, N., Sato, Y., Saruta, C., Nishibe, H., Sadakata, T., Shinoda, Y., Hayashi, K., Mishima, Y., Baba, H., and Furuichi, T. Phospholipase D Family Member 4, a Transmembrane Glycoprotein with no Phospholipase D activity, Expression in Spleen and Early Postnatal Microglia. PLoS ONE 5(11):e13932, 2010

  32. Sadakata, T., Shinoda, Y., Sekine, Y., Saruta, C., Itakura, M., Takahashi, M., and Furuichi, T. Interaction of CAPS1 with the class II Arf small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. J. Biol. Chem. 285:38710-38719, 2010

  33. Furutama, D., Morita, N., Takano, R., Sekine, Y., Sadakata, T., Shinoda, Y., Hayashi, K., Mishima, Y., Mikoshiba, K., Hawkes, R., and Furuichi, T. Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum. J. Neurosci. Res. 88:2810-2825, 2010

  34. Shiraishi-Yamaguchi, Y., Sato, Y., Sakai, R., Mizutani, A., Knopfel, T., Mori, N., Mikoshiba, K., and Furuichi, T. Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines. BMC Neurosci. 10(1):25, 2009

  35. Amano, K., Fujii, M., Arata, S., Tojima, T., Ogawa, M., Morita, N., Shimohata, A., Furuichi, T., Itohara, S., Kamiguchi, H., Korenberg, J.R., Arata, A., and Yamakawa, K. DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death. J. Neurosci. 29:2984-2996, 2009

  36. Yoshikawa, F., Sato, Y., Tohyama, K., Akagi, T., Hashikawa, T., Nagakura-Takagi, Y., Sekine, Y., Morita, N., Baba, H., Suzuki, Y., Sugano, S., Sato, A., and Furuichi, T. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. J. Biol. Chem. 283:20830-20840, 2008

  37. Mizutani, A., Kuroda, Y., Futatsugi, A., Furuichi, T., and Mikoshiba, K. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. J. Neurosci. 28:5369-5382, 2008

  38. Suzuki, T., Inoue, I., Yamagata, T., Morita, N., Furuichi, T., and Yamakawa, K. Sequential expression of Efhc1/myoclonin1 in choroid plexus and ependymal cell cilia. Biochem. Biophys. Res. Commun. 367:226-233, 2008

  39. Tsutsumi, K., Tomomura, M., Furuichi, T., and Hisanaga, S. Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src. Genes to Cells 13:949-964, 2008

  40. Huang, J., Furuya, A., and Furuichi, T. Very-KIND, a KIND domain-containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2. J. Cell Biol. 179:539-552, 2007

  41. Sadakata, T., Kakegawa, W., Mizoguchi, A., Washida, M., Katoh-Semba, R., Shutoh, F., Okamoto, T., Nakashima, H., Kimura, K., Tanaka, M., Sekine, Y., Itohara, S., Yuzaki, M., Nagao, S., and Furuichi, T. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. J. Neurosci. 27:2472-2482, 2007

  42. Sadakata, T., Washida, M., Iwayama, Y., Shoji, S., Sato, Y., Ohkura, T., Kato-Semba, R., Nakajima, M., Sekine, Y., Tanaka, M., Nakamura, K., Iwata, Y., Tsuchiya, K.J., Mori, N., Detera-Wadleigh, S.D., Ichikawa, H., Itohara, S., Yoshikawa, T., and Furuichi, T. Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. J. Clin. Invest. 117:931-943, 2007

  43. Sadakata T, Washida M, and Furuichi T. Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. BMC Neurosci. 8:25, 2007

  44. Sadakata, T., Washida, M., Morita, N., and Furuichi, T. Tissue distribution of Ca2+-dependent activator protein for secretion family members CAPS1 and CAPS2 in mice. J. Histochem. Cytochem. 55:301-311, 2007

  45. Aruga, J., Yoshikawa, F., Nozaki, Y., Sakaki, Y., Toyoda, A., and Furuichi, T. An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. J. Neurochem. 102:1533-1547, 2007

  46. Tomomura, M., Morita, N., Yoshikawa, F., Konishi, A., Akiyama, H., Furuichi, T., and Kamiguchi, H.Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Neurosci. 148:510-521, 2007

  47. Ohnishi, T., Ohba, H., Seo, K.C., Im, J., Sato, Y., Iwayama, Y., Furuichi, T., Chung, S.K., and Yoshikawa, T. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J. Biol. Chem. 282:637-646, 2007

  48. Ajima, R., Kajiya, K., Inoue, T., Tani, M., Shiraishi-Yamaguchi, Y., Maeda, M., Segawa, T., Furuichi, T., Sutoh, K., and Yokota, J. HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. Biochem. Biophys. Res. Commun. 356:851-856, 2007

  49. Ogiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa Y., Obata, K., Furuichi, T., Hensch, T.K., and Yamakawa, K. NaV1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 27:5903-5914, 2007

  50. Kuwajima, M., Dehoff, M.H., Furuichi, T., Worley, P.F., Hall, R.A., and Smith, Y. Localization and expression of group I metabotropic glutamate receptors in the mouse striatum, globus pallidus, and subthalamic nucleus: regulatory effects of MPTP treatment and constitutive Homer deletion. J. Neurosci. 27:6249-6260, 2007

  51. Huang, J., Sakai, R., and Furuichi, T. The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons. Mol. Biol. Cell. 17:3187-3196, 2006

  52. Sadakata, T., Itakura, M., Kozaki, S., Sekine, Y., Takahashi, M., and Furuichi, T. Differential distributions of the Ca2+-dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain. J. Comp. Neurol. 495:735-753, 2006

  53. Sadakata, T. and Furuichi, T. Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain. Neurosci. Lett. 405:217-222, 2006

  54. Kawano, S., Otsu, K., Kuruma, A., Shoji, S., Yanagida, E., Muto, Y., Yoshikawa, F., Hirayama, Y., Mikoshiba, K., and Furuichi, T. ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells. Cell Calcium 39:313-324, 2006

  55. Tomomura, M. and Furuichi, T. Apoptosis-associated tyrosine kinase (AATYK) has differential Ca2+-dependent phosphorylation states in response to survival and apoptotic conditions in cerebellar granule cells. J. Biol. Chem. 280:35157-35163, 2005

  56. Matsuki, T., Hori, G., and Furuichi, T. Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system. Mol. Brain Res. 136:231-254, 2005

  57. Iwai, M., Tateishi, Y., Hattori, M., Mizutani, A., Nakamura, T., Futatsugi, A., Inoue, T., Furuichi, T., Michikawa, T., and Mikoshiba, K. Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant. J. Biol. Chem. 280:10305-10317, 2005

  58. Sadakata, T., Mizoguchi, A., Sato, Y., Katoh-Semba, R., Fukuda, M., Mikoshiba, K., and Furuichi, T. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J. Neurosci. 24:43-52, 2004

  59. Shiraishi, Y., Mizutani, A., Yuasa, S., Mikoshiba, K., and Furuichi, T. Differential expression of Homer family proteins in the developing mouse brain. J. Comp. Neurol. 473:582-599, 2004

  60. Sato, Y., Shiraishi, Y., and Furuichi, T. Cell specificity and efficiency of the Semliki forest virus vector- and adenovirus vector-mediated gene expression in mouse cerebellum. J. Neurosci. Methods 137:111-121, 2004

  61. Kakinuma, Y., Saito, F., Osawa, S., Furuichi, T., and Miura, M. A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of beta-catenin. J. Neurosci. Res. 77:653-661, 2004

  62. Yanagida, E., Shoji, S., Hirayama, Y., Yoshikawa, F., Otsu, K., Uematsu, H., Hiraoka, M., Furuichi, T., and Kawano, S. Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells. Cell Calcium 36:135-146, 2004

  63. Shiraishi, Y., Mizutani, A., Mikoshiba, K., and Furuichi, T. Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons. Mol. Cell. Neurosci. 22:188-201, 2003

  64. Shiraishi, Y., Mizutani, A., Yuasa, S., Mikoshiba, K., and Furuichi, T. Glutamate-induced declustering of post-synaptic adaptor protein Cupidin (Homer2/vesl-2) in cultured cerebellar granule cells. J. Neurochem. 87:364-376, 2003

  65. Uchida, K., Miyauchi, H., Furuichi, T., Michikawa, T., and Mikoshiba, K. Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 278:16551-16560, 2003

  66. Tomomura, M., Hasegawa, Y., Hashikawa, T., Tomomura, A., Yuzaki, M., Furuichi, T., and Yano, R. Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain. Mol. Brain Res. 112:103-112, 2003

  67. Bosanac, I., Alattia, J.R., Mal, T.K., Chan, J., Talarico, S., Tong, F.K., Tong, K.I., Yoshikawa, F., Furuichi, T., Iwai, M., Michikawa, T., Mikoshiba, K., and Ikura, M. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420:696-700, 2002 (IF 31.434)

  68. Iwasaki, H., Chiba, K., Uchiyama, T., Yoshikawa, F., Suzuki, F., Ikeda, M., Furuichi, T., and Mikoshiba, K. Molecular characterization of the starfish inositol 1,4,5-trisphosphate receptor and its role during oocyte maturation and fertilization. J. Biol. Chem. 277:2763-2772, 2002

  69. Uchiyama, T., Yoshikawa, F., Hishida, A., Furuichi, T., and Mikoshiba, K. A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP3) absorbent traps IP3, resulting in specific inhibition of IP3-mediated calcium signaling. J. Biol. Chem. 277:8106-8113, 2002

  70. Kagami, Y., and Furuichi, T. Investigation of differentially expressed genes during the development of mouse cerebellum. Gene Expr. Patterns 1:39-59, 2001

  71. Shiraishi, Y., Mizutani, A., Bito, H., Fujisawa, K., Narumiya, S., Mikoshiba, K., and Furuichi, T. Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated Rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J. Neurosci. 19:8389-8400, 1999

  72. Michikawa, T., Hirota, J., Kawano, S., Hiraoka, M., Yamada, M., Furuichi, T., and Mikoshiba, K. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor. Neuron 23:799-808, 1999

  73. Hirota, J., Furuichi, T., and Mikoshiba, K. Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for Caspase-3 and is cleaved during apoptosis in a Caspase-3-dependent manner. J. Biol. Chem. 274:34433-34437, 1999

  74. Baylis, H.A., Furuichi, T., Yoshikawa, F., Mikoshiba, K., and Sattelle, D.B. Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1). J. Mol. Biol. 294:467-476, 1999

  75. Zhu, C.C., Furuichi, T., Mikoshiba, K., and Wojcikiewicz, R.J.H. Inositol 1,4,5-trisphosphate receptor down-regulation is activated directly by inositol 1,4,5-trisphosphate binding. J. Biol. Chem. 274:3476-3484, 1999

  76. Yoshikawa, F., Iwasaki, H., Michikawa, T., Furuichi, T., and Mikoshiba, K. Trypsinized cerebellar inositol 1,4,5-trisphosphate receptor: structural and functional coupling of cleaved ligand binding and channel domains. J. Biol. Chem. 274:316-327, 1999

  77. Yoshikawa, F., Iwasaki, H., Michikawa, T., Furuichi, T., and Mikoshiba, K. Cooperative formation of the ligand-binding site of the inositol 1,4,5-trisphosphate receptor by two separable domains. J. Biol. Chem. 274:328-334, 1999

  78. Yoshikawa, F., Uchiyama, T., Iwasaki, H., Tomomori-Satoh, C., Tanaka, T., Furuichi, T., and Mikoshiba, K. High efficient expression of the functional ligand binding site of the inositol 1,4,5-trisphosphate receptor in Escherichia coli. Biochem. Biophys. Res. Commun. 257:792-797, 1999

  79. Natsume, T., Hirota, J., Yohikawa, F., Furuichi, T., and Mikoshiba, K. Real time analysis of interaction between inositol 1,4,5-Trisphosphate receptor type 1 and its ligand. Biochem. Biophys. Res. Commun. 260:527-533, 1999

  80. Konishi, Y., Ohkawa, N., Makino, Y., Okubo, H., Kageyama, R., Furuichi, T., Mikoshiba, K., and Tamura, T. Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factor. J. Neurochem. 72:1717-1724, 1999

  81. Mitsuyama, F., Sawai, T., Carafoli, E., Furuichi, T., and Mikoshiba, K. Microinjection of Ca2+ store-enriched microsome fractions to dividing newt eggs induces extra-cleavage furrows via inositol 1,4,5-trisphosphate-induced Ca2+ release. Dev. Biol. 214:160-167, 1999

  82. Hirota, J., Michikawa, T., Natsume, T., Furuichi, T., and Mikoshiba. K. Calmodulin inhibits inositol 1,4,5-trisphosphate-induced calcium release through the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1. FEBS Lett. 456:322-326, 1999

  83. Hitota, J., Baba, M., Matsumoto, M., Furuichi, T., Takatsu, K., and Mikoshiba, K. T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type -1-deficient mice: is IP3R type 1 essential for T-cell-receptor signalling? Biochem. J. 333:615-619, 1998

  84. Monkawa, T., Hayashi, M., Miyawaki, A., Sugiyama, T., Yamamoto-Hino, M., Hasegawa, M., Furuichi, T., Mikoshiba, K., and Saruta, T. Localization of inositol 1,4,5-trisphosphate receptors in the rat kidney. Kidney Int. 53:296-301, 1998

  85. Yamamoto-Hino, M., Miyawaki, A., Segawa, A., Adachi, E., Yamashina, S., Fujimoto, T., Sugiyama, T., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Apical vesicles bearing inositol 1,4,5-trisphosphate receptors in the Ca2+ initiation site of ductal epithelium of submandibular gland. J. Cell Biol. 141:135-142, 1998

  86. Morikawa, K., Ohbayashi, T., Nakagawa M., Konishi, Y., Makino, Y., Yamada, M., Miyawaki, A., Furuichi, T., Mikoshiba, K., and Tamura, T. Transcriptional initiation sites and promoter structure of the mouse type 2 inositol 1,4,5-trisphosphate receptor gene. Gene 196:181-185, 1997

  87. Konishi, Y., Kobayashi, Y., Kishimoto, T., Makino Y., Miyawaki, A., Furuichi, T., Okano, H., Mikoshiba, K., and Tamura, T. Demonstration of an E-box and its CNS-related binding factors for transcriptional regulation of the mouse type 1 inositol 1,4,5-trisphosphate receptor gene. J. Neurochem. 69:476-484, 1997

  88. Sayers, L.G., Miyawaki, A., Muto, A., Takeshita, H., Yamamoto, A., Michikawa, T., Furuichi, T., and Mikoshiba, K. Intracellular targeting and homotetramer formation of a truncated inositol 1,4,5-trisphosphate receptor-green fluorescent protein chimera in Xenopus laevis oocytes: evidence for the involvement of the transmembrane spanning domain in endoplasmic reticulum targeting and homotetramer complex formation. Biochem. J. 323:273-280, 1997

  89. Yoneshima, H., Miyawaki, A., Michikawa, T., Furuichi, T., and Mikoshiba, K. Ca2+ differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptors. Biochem. J. 322:591-596, 1997

  90. el-Daher, S.S., Eigenthaler, M., Walter, U., Furuichi, T., Miyawaki, A., Mikoshiba, K., Kakkar, V.V., and Authi, K.S. Distribution and activation of cAMP- and cGMP-dependent protein kinases in highly purified human platelet plasma and intracellular membranes. Thrombosis and Haemostasis 76:1063-1071, 1996

  91. Yamada, H., Yamamoto, A., Yodozawa, S., Kozaki, S., Takahashi, M., Morita, M., Michibata, H., Furuichi, T., Mikoshiba, K., and Moriyama, Y. Microvesicle-mediated exocytosis of glutamate is a novel paracrine-like chemical transduction mechanism and inhibits melatonin secretion in rat pinealocytes. J. Pineal Res. 21:175-191, 1996

  92. Yoshikawa, F., Morita, M., Monkawa, T., Michikawa, T., Furuichi, T., and Mikoshiba, K. Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 271:18277-18284, 1996

  93. Li, M., Miyawaki, A., Yamamoto-Hino, M., Yasutomi, D., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Differential cellular expression of three types of inositol 1,4,5-trisphosphate receptor in rat gastrointestinal epithelium. Biomed. Res. 17:45-51, 1996

  94. Furutama, D., Shimoda, K., Yoshikawa, S., Miyawaki, A., Furuichi, T., and Mikoshiba, K.Functional expression of the type 1 inositol 1,4,5-trisphosphate receptor promoter-lacZ fusion gene in transgenic mice. J. Neurochem. 66:1793-1801, 1996

  95. Matsumoto, M., Nakagawa, T., Inoue, T., Nagara, E., Tanaka, K., Takano, H., Minowa, O., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., Miyawaki, A., Fukuuchi, Y., Furuichi, T., Okano, H., Mikoshiba, K., and Noda, T. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphtate receptor. Nature 379:168-171, 1996

  96. Hirota, J., Michikawa, T., Miyawaki, A., Furuichi, T., Okura, I., and Mikoshiba, K. Kinetics of calcium release by immunoaffinity-purified inositol 1,4,5-trisphosphate receptor in reconstituted lipid vesicles. J. Biol. Chem. 270:19046-19051, 1995

  97. Hirota, J., Michikawa, T., Miyawaki, A., Takahashi, M., Takazawa, K., Okura, I., Furuichi, T., and Mikoshiba, K. Adenophostin-mediated quantal Ca2+ release in the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1. FEBS Lett. 368:248-252, 1995

  98. Yamada, M., Miyawaki, A., Saito, K., Nakajima, T., Yamamoto-Hino, M., Ryo, Y., Furuichi, T., and Mikoshiba, K. The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor. Biochem. J. 308:83-88, 1995

  99. Monkawa, T., Miyawaki, A., Sugiyama, T., Yoneshima, H., Yamamoto-Hino, M., Furuichi, T., Saruta, T., Hasegawa, M., and Mikoshiba, K. Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits. J. Biol. Chem. 270:14700-14704, 1995

  100. Fujino, I., Yamada, N., Miyawaki, A., Hasegawa, M., Furuichi, T., and Mikoshiba, K. Differential expression of type 2 and type 3 inositol 1,4,5-trisphosphate receptor mRNAs in various mouse tissues: in situ hybridization study. Cell Tissue Res. 280:201-210, 1995

  101. Yamamoto-Hino, M., Miyawaki, A., Kawano, H., Sugiyama, T., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Immunohistochemical study of inositol 1,4,5-trisphosphate receptor type 3 in rat central nervous system. NeuroRep. 6:273-276, 1995

  102. Wojcikiewicz, R.J.H., Furuichi, T., Nakade, S., Mikoshiba, K., and Nahorski, S.R. Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation. J. Biol. Chem. 269:7963-7969, 1994

  103. Wakamori, M., Niidome, T., Furutama, D., Furuichi, T., Mikoshiba, K., Fujita, Y., Tanaka, I., Katayama, K., Yatani, A., Schwartz, A., and Mori, Y. Distinctive functional properties of the neuronal BII (class E) calcium channel. Recept. Channels 2:303-314, 1994

  104. Aruga, J., Yokota, N., Hashimoto, M., Furuichi, T., Fukuda, M., and Mikoshiba, K. A novel zinc finger protein, Zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J. Neurochem. 63:1880-1890, 1994

  105. Yamada, N., Makino, Y., Clark, R.A., Pearson, D.W., Mattei, M.G., Guenet, J.L., Ohama, E., Fujino, I., Miyawaki, A., Furuichi, T., and Mikoshiba, K. Human inositol 1,4,5-trisphosphate type 1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization. Biochem. J. 302:781-790, 1994

  106. Sugiyama, T., Yamamoto-Hino, M., Miyawaki, A., Furuichi, T., Mikoshiba, K., and Hasegawa, M. Subtypes of inositol 1,4,5-trisphosphate receptor in human hematopoietic cell lines: dynamic aspects of their cell-type specific expression. FEBS Lett. 349:191-196, 1994

  107. Yamamoto-Hino, M., Sugiyama, T., Hikichi K., Mattei, M.G., Hasegawa, K., Sekine S., Sakurada, K., Miyawaki, A., Furuichi, T., Hasegawa, M., and Mikoshiba, K. Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors. Recept. Channels 2:9-22, 1994

  108. Michikawa, T., Hamanaka, H., Otsu, H., Yamamoto, A., Miyawaki, A., Furuichi, T., Tashiro, Y., and Mikoshiba, K. Transmembrane topology and sites of N-glycosylation of inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 269:9184-9189, 1994

  109. Yuzaki, M., Furuichi, T., Mikoshiba, K., and Kagawa, Y. A stimulus paradigm inducing long-term desensitization of AMPA receptors evokes a specific increase in BDNF mRNA in cerebellar slices. Learning and Memory 1:230-242, 1994

  110. Furuichi, T., Furutama, D., Hakamata, Y., Nakai, J., Takeshima, H., and Mikoshiba, K. Multiple types of ryanodine receptors/Ca2+ release channels are differentially expressed in rabbit brain. J. Neurosci. 14:4794-4805, 1994

  111. Ryo, Y., Miyawaki, A., Furuichi, T., and Mikoshiba, K. Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice. J. Neurosci. Res. 32:19-32, 1993

  112. Kume, S., Muto, A., Aruga, J., Nakagawa, T., Furuichi, T., Nakade, S., Okano, H., and Mikoshiba, K. The Xenopus IP3 receptor: Structure, function, and localization in oocytes and eggs. Cell 73:555-570, 1993

  113. Yoshikawa, Y., Miyamoto, I., Aruga, J., Furuichi, T., Okano, H., and Mikoshiba, K. Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. J. Neurochem. 60:1570-1573, 1993

  114. Fujita, Y., Mynlieff, M., Dirksen, R.T., Kim, M.S., Niidome, T., Nakai, J., Friedrich, T., Iwabe, N., Miyata, T., Furuichi, T., Furutama, D., Mikoshiba, K., Mori, Y., and Beam, K.G. Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain. Neuron 10:585-598, 1993

  115. Furuichi, T., Simon-Chazottes, D., Fujino, I., Yamada, N., Hasegawa, M., Miyawaki, A., Yoshikawa, S., Guenet, J.L., and Mikoshiba, K. Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. Recept. Channels 1:11-24, 1993

  116. Yoshikawa, S., Tanimura, T., Miyawaki, A., Nakanura, M., Yuzaki, M., Furuichi, T., and Mikoshiba, K. Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster. J. Biol. Chem. 267:16613-16619, 1992

  117. Miyawaki, A., Furuichi, T., Ryou, Y., Yoshikawa, S., Nakagawa, T., Saitoh, T., and Mikoshiba, K. Structure-function relationships of the mouse inositol 1,4,5-trisphosphate receptor. Proc. Natl. Acad. Sci. U.S.A. 88: 4911-4915, 1991

  118. Nakagawa, T., Okano, H., Furuichi, T., Aruga, J., and Mikoshiba, K. The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner. Proc. Natl. Acad. Sci. U.S.A. 88:6244-6248, 1991

  119. Mori, Y., Friedrich, T., Kim, M.S., Mikami, A., Nakai, J., Ruth, P., Bosse, E., Hofmann, F., Flockerzi, V., Furuichi, T., Mikoshiba, K., Imoto, K., Tanabe, T., and Numa, S. Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature 350:398-402, 1991

  120. Nakahira, K., Ikenaka, K., Wada, K., Tamura, T., Furuichi, T., and Mikoshiba, K. Structure of the 68-kDa neurofilament gene and regulation of its expression. J. Biol. Chem. 265:19786-19791, 1990

  121. Miyawaki, A., Furuichi, T., Maeda, N., and Mikoshiba, K. Expressed cerebellar-type inositol 1,4,5-trisphosphate receptor, P400, has calcium release activity in a fibroblast L cell line. Neuron 5:11-18, 1990

  122. Inoue, T., Tamura, T., Furuichi, T., and Mikoshiba, K. Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter. J. Biol. Chem. 265:19065-19070, 1990

  123. Furuichi, T., Shiota, C., and Mikoshiba, K. Distribution of inositol 1,4,5-trisphosphate receptor mRNA in mouse tissues. FEBS Lett. 267:85-88, 1990

  124. Furuichi, T., Yoshikawa, S., and Mikoshiba, K. Nucleotide sequence of cDNA encoding P400 protein in the mouse cerebellum. Nucleic Acids Res. 17:5385-5386, 1989

  125. Furuichi, T., Yoshikawa, S., Miyawaki, A., Wada, K., Maeda, N., and Mikoshiba, K. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature 342:32-38, 1989

  126. Ikenaka, K., Furuichi, T., Iwasaki, Y., Moriguchi, A., Okano, H., and Mikoshiba, K. Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant mice. J. Mol. Biol. 199:587-596, 1988

  127. Dhundale, A., Furuichi, T., Inouye, M., and Inouye, S. Mutations that affect production of branched RNA-linked msDNA in Myxococcus xanthus. J. Bacteriol. 170:5620-5624, 1988

  128. Moriguchi, A., Ikenaka, K., Furuichi, T., Okano, H., Iwasaki, Y., and Mikoshiba, K. The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice. Gene 55:333-337, 1987

  129. Dhundale, A., Lampson, B., Furuichi, T., Inouye, M., and Inouye, S. Structure of msDNA from Myxococcus xanthus: evidence for a long, self-annealing RNA precursor for the covalently linked, branched RNA. Cell 51:1105-1112, 1987

  130. Furuichi, T., Inouye, S., and Inouye, M. Biosynthesis and structure of stable branched RNA covalently linked to the 5' end of multicopy single-stranded DNA of Stigmatella aurantiaca. Cell 48:55-62, 1987

  131. Furuichi, T., Dhundale, A., Inouye, M., and Inouye, S. Branched RNA covalently linked to the 5' end of a single-stranded DNA in Stigmatella aurantiaca: structure of msDNA. Cell 48:47-53, 1987

  132. Komano, T., Kubo, A., Kayanuma, T., Furuichi, T., and Nisioka, T. Highly mobile DNA segment of incI-alpha plasmid R64: a clustered inversion region. J. Bacteriol. 165:94-100, 1986

  133. Dhundale, A.R., Furuichi, T., Inouye, S., and Inouye, M. Distribution of multicopy single-stranded DNA among myxobacteria and related species. J. Bacteriol. 164:914-917, 1985

  134. Furuichi, T., Inouye, M., and Inouye, S. Novel one-step cloning vector with a transposable element: application to the Myxococcus xanthus genome. J. Bacteriol. 164:270-275, 1985

  135. Teintze, M., Thomas, R., Furuichi, T., Inouye, M., and Inouye, S. Two homologous genes coding for spore-specific proteins are expressed at different times during development of Myxococcus xanthus. J. Bacteriol. 163:121-125, 1985

  136. Furuichi, T., Komano, T., Inouye, M., and Inouye, S. Functional complementation between the two homologous genes, ops and tps, during differentiation of Myxococcus xanthus. Mol. Gen. Genet. 199:434-439, 1985

  137. Yee, T., Furuichi, T., Inouye, S., and Inouye, M. Multicopy single-stranded DNA isolated from a gram-negative bacterium, Myxococcus xanthus. Cell 38:203-209, 1984

  138. Furuichi, T., Komano, T., and Nisioka, T. Physical and genetic analyses of the Inc-I-alpha plasmid R64. J. Bacteriol. 158:997-1004, 1984

 

 

Reviews, Chapters & Books

  1. Sadakata T, Shinoda Y, Sato A, Iguchi H, Ishii C, Matsuo M, Yamaga R, Furuichi T. Mouse models of mutations and variations in autism spectrum disorder-associated genes: mice expressing caps2/cadps2 copy number and alternative splicing variants. Int J Environ Res Public Health. 10(12):6335-6353, 2013.

  2. Shinoda, Y., Sadakata, T., and Furuichi, T. Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-level Approach to Autistic-like Behavior in Mice. Exp. Anim. 62(2), 71-78, 2013

  3. Furuichi, T., Shiraishi-Yamaguchi, Y., Sato, A., Sadakata, T., Huang, J., Shinoda, Y., Hayashi, K., Mishima, Y., Tomomura, M., Nishibe, H., and Yoshikawa, F. Systematizing and cloning of genes involved in the cerebellar cortex circuit development. Neurochem Res. 36:1241-1252, 2011

  4. Sadakata, T. and Furuichi, T. Ca2+-dependent activator protein for secretion 2 and autistic-like phenotypes. Neurosci Res. 67:197-202, 2010

  5. Sadakata, T. and Furuichi, T. Developmentally-regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF release and is associated with autism susceptibility. The Cerebellum 8:312-322, 2009

  6. Sato, A., Sekine, Y., Saruta, C., Nishibe, H., Morita, N., Sato, Y., Sadakata, T., Shinoda, Y., Kojima, T., and Furuichi, T. Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum. Neural Networks 21:1056-1069, 2008

  7. Shiraishi-Yamaguchi, Y. and Furuichi, T. The Homer family proteins. Genome Biology 8:206.1-206.12, 2007

  8. Sato, A., Morita, N., Sadakata, T., Yoshikawa, F., Shiraishi-Yamaguchi, Y., Huang, JH., Shoji, S., Tomomura, M., Sato, Y., Suga, E., Sekine, Y., Kitamura, A., Shibata, Y., and Furuichi, T. Deciphering the genetic blueprint of cerebellar development by the gene expression profiling informatics. Neural information processing. In Lecture Notes in Computer Science 3316:880-884, 2004, Springer-Verlag, Berlin, Heidelberger, Germany.

  9. Miyawaki, A., Matheson, J.M., Sayers, L.G., Muto, A., Michikawa, T., Furuichi, T., and Mikoshiba, K. Expression of green fluorescent protein and inositol 1,4,5-triphosphate receptor in Xenopus laevis oocytes. In Methods in Enzymology Vol. 302 Green Fluorescent Protein (Conn, P.M., ed.), pp225-233, 1999, Academic Press, San Diego, CA.

  10. Furuichi, T., Michikawa, T., and Mikoshiba, K. Intracellular calcium channels. In Calcium as cellular regulator. (Carafoli, E. and Klee, C., eds.), pp200-248, 1999, Oxford Univ. Press, NY.

  11. Mikoshiba, K., Furuichi, T., Miyawaki, A., Michikawa, T., Yamamoto-Hino, M., Hirota, J., Tekei, K., Inoue, T., Kume, S., Matsumoto, M., and Muto, A. Role of inositol 1,4,5-trisphosphate (IP3) receptor/Ca2+ signaling in cell function. In Challenges for Neuroscience in the 21st Century, Taniguchi Symposia on Brain Sciences. (Hayaishi, O., Ito, M., Sano, Y., Takagi, H., Tsukada, Y., and Nakajima, T., eds) No. 22, pp121-146, 1999, Japan Scientific Societies Press, KARGER, Basel.

  12. Michikawa, T., Miyawaki, A., Furuichi, T., and Mikoshiba, K. Inositol 1,4,5-trisphosphate receptors and calcium signaling. Crit Rev Neurobiol. 10:39-55, 1996

  13. Mikoshiba, K., Furuichi, T., and Miyawaki, A. IP3-sensitive calcium channel. In Biomembranes Vol. 6 Transmembrane receptors and channels (Lee, A.G., ed.), pp273-289, 1996, JAI Press Inc., Greenwich, CT.

  14. Mikoshiba K., Okano H., Miyawaki A., Furuichi T., Ikenaka K. Molecular genetic analyses of myelin deficiency and cerebellar ataxia. Prog Brain Res. 105:23-41, 1995

  15. Furuichi, T. and Mikoshiba, K. Inositol 1,4,5-trisphosphate receptor-mediated Ca2+ signaling in the brain. J. Neurochem. 64:953-960, 1995

  16. Mikoshiba, K., Furuichi, T., and Miyawaki, A. Structure and function of IP3 receptors. Semin. Cell Biol. 5:273-281, 1994 (=Semin. Cell Dev. Biol.)

  17. Furuichi, T., Kohda, K., Miyawaki, A., and Mikoshiba, K. Intracellular channels. Curr. Opin. Neurobiol. 4:294-303, 1994

  18. Mikoshiba K., Furuichi T., Miyawaki A., Yoshikawa S., Nakade S., Michikawa T., Nakagawa T., Okano H., Kume S., Muto A., Aruga, J., Yamada, N., Hamanaka, Y., Fujino, I., and Kobayashi, M. Structure and function of inositol 1,4,5-trisphosphate receptor. Ann N Y Acad Sci. 707:178-97, 1993

  19. Mikoshiba, K., Furuichi, T., Miyawaki, A., Yoshikawa, S., Nakagawa, T., Yamada, N., Hamanaka, Y., Fujino, I., Michikawa, T., Ryo, Y., and Okano, H. Inositol trisphosphate receptor and Ca2+ signalling, in Signalling mechanisms involved in control of cell growth. Phil. Trans. R. Soc. London. B (Hall, A., Hunt, R.T., Parker P.J., and Waterfield M.D., eds.), 340:345-349, 1993

  20. Mikoshiba, K., Furuichi, T., Miyawaki, A., Yoshikawa, S., Nakagawa, T., Kume, S., Muto, A., Okano, H., Yamada, N., Michikawa, T., Hamanaka, H., and Ryo, Y. Structure and function of inositol trisphosphate receptor. In Frontiers in Biomedical Research (Hartmann, D., Furuichi, Y., and Drews, J., eds.), Clinical Pharmacology 9, pp115-121, 1993, W. Zuckschwerdt Verlag, Munchen.

  21. Mikoshiba, K., Furuichi, T., Miyawaki, A., Yoshikawa, S., Nakagawa, T., Aruga, J., Okano, H., and Yamada, N. Inositol 1,4,5-trisphosphate (IP3) receptors. In Clinical Pharmacology 15, Suppl 1 Pt A: 62A-63A, 1992.

  22. Mikoshiba, K., Furuichi, T., Miyawaki, A., Yoshikawa, S., Nakade, S., Nakagawa, T., Nakanishi, S., Aruga, J., Okano, H., Niinobe, M., and Maeda, N. Structure and function of the inositol 1,4,5-trisphospahte receptor. In a-Adrenoceptors pp55-66, 1992, Excerpta Medica, Ltd. Tokyo.

  23. Mikoshiba, K., Furuichi, T., Miyawaki, A., Yoshikawa, S., Nakagawa, T., Yamada, N., Hamanaka, Y., Fujino, I., Michikawa, Y., Ryo, Y., and Okano, H. Inositol 1,4,5-trisphospahte receptor. In Neurotransmitter Receptors and Intracellular Signaling pp55-60, 1992, Excerpta Medica, Ltd. Tokyo.

  24. Mikoshiba, K., Furuichi, T., Miyawaki, A., Yoshikawa, S., Maeda, N., Niinobe, M., Nakade, S., Nakagawa, T., Okano, H., and Aruga, J. The inositol 1,4,5-trisphosphate receptor, in Interactions among cell signalling systems. In Ciba foundation symposium 164, pp17-35, 1992, Wiley, Chichester.

  25. Furuichi, T., Miyawaki, A., Maeda, N., Nakade, S., Nakanishi, S., Nakagawa, T., Yoshikawa, S., and Mikoshiba, K. Structure and function of the inositol 1,4,5-trisphosphate receptor. In Neuroreceptors, ion channels and the brain. (Kawai, N., Nakajima, T., and Barnard, E., eds.), pp103-111, 1992, Elsevier Science Publications, Amsterdam.

  26. Mikoshiba, K., Furuichi, T., Maeda, N., Yoshikawa, S., Miyawaki, A., Niinobe, M., and Wada, K. Primary structure and functional expression of the inositol 1,4,5-trisphosphate receptor, P400, in Neuroreceptor mechanisms in brain. In Advances in experimental medicine & biology Vol. 287 (Kito, S. et al., eds.), pp83-95, 1991, Plenum Press, New York.

  27. Mikoshiba, K., Furuichi, T., Maeda, N., Yoshikawa, S., Miyawaki, A., Niinobe, M., and Wada, K. Primary structure and functional expression of the inositol 1,4,5-trisphosphate receptor, P400, In Neuroreceptor mechanisms in brain. Advances in experimental medicine & biology Vol. 287 (Kito, S. et al., eds.), pp83-95, 1991, Plenum Press, New York.

  28. Inouye, S., Furuichi, T., Dhundale, A., and Inouye, M. Stable branched RNA covalently linked to the 5’ end of a single-stranded DNA of Myxobacteria. In Molecular Biology of RNA: New Perspectives. (Inouye, M. and Dudock, B.S. eds.), pp271-284, 1987, Academic Press, San Diego, CA.

  29. Teinze, M., Furuichi, T., Thomas, R., Inouye, M., and Inouye, S. Differential expression of two homologous genes coding for spore-specific proteins in Myxococcus xanthus. In Spores IX: the molecular biology of microbial differentiation. (Hoch, J. and Setlow, P., eds.), pp253-260, 1985, American Society for Microbiology, Washington, D.C.

Teiichi Furuichi

  Tokyo University of Science

古市貞一 東京理科大学

Tokyo University of Science, Laboratory of Moleuclar Neuroscience (FURUICHI LAB)